Panos Dragonas studied architecture at the National Technical University of Athens (Diploma in Architecture, 1992) and at Columbia University in New York (MS AAD, 1993) as a Fulbright scholar. Since 2000, he has been teaching architectural and urban design courses at the TΑΜΠΠ (Technical University of Athens, School of Architecture). He also teaches an elective course titled "Cinema, Architecture, and the City."

In 2020, he established the architectural studio "Dragonas architecture" in Athens. His design work has been distinguished in 10 architectural competitions and has been published in international magazines such as L’architecture d’aujourd’hui, Archi, Bauwelt, and Blueprint. He has curated special features and published extensively on topics related to contemporary Greek architecture, public space, and the issues of the contemporary city in international architectural journals like AA Files, Archithese, Domes, MASContext, Monu, and Stavba. From 2001 to 2013, he was an editorial consultant for the annual reviews Architectural Themes and Space + Arts. In 2012, he was the national commissioner and co-curator of the exhibition "Made in Athens", representing Greece at the 13th International Architecture Exhibition - la Biennale di Venezia (2012). In 2017, he co-curated the exhibition "Tomorrows: Urban Fictions for Possible Futures," presented in Athens and Nantes, France (2019). He has also curated - individually or in collaboration - exhibitions such as "Adhocracy [Athens]" (2015), "Rethink Athens" (2013), "14F/21GR. New Architects from France and Greece" (2012), and the "2nd Biennale of Young Greek Architects" (1998), as well as a series of public discussions titled "Rethink Athens – Urban Challenges" focusing on contemporary city and the social implications of urban renewal programs in Athens.

In 2016, he was a visiting researcher at the Stanley J. Seeger '52 Center for Hellenic Studies at Princeton University.

His research and design work focuses on the transformations of Greek cities during economic and social crises and on the connection between cinema, architecture, and the modern city. Currently, two of his research projects are in progress: the first examines the dissemination of modern living patterns in Athens through juxtaposition and cinema, while the second reassesses Takis Zenetos's "Electronic Urbanism" in light of current social and technological developments.