Nektarios Farmakis was born in 1980 in Agrinio. He studied Law at Democritus University of Thrace and holds a postgraduate degree in Civil Procedural Law. He is a lawyer at the Supreme Court (Areios Pagos) and a member of the Bar Association of Agrinio.

In 2010, at the age of 30, he was elected for the first time as a Regional Councilor of Western Greece, receiving the most votes in the Regional Unit of Aetolia-Acarnania. In the 2014 Regional Elections, he ran as a candidate for Deputy Regional Governor of the Regional Unit of Aetolia-Acarnania.In the Regional Elections of 2014, he ran as a candidate for Deputy Regional Governor of Aetolia-Acarnania.

In September 2019, he was elected Regional Governor of Western Greece as the head of the "Starting Over" coalition, winning with 56.38% in the second round.

He was re-elected as Regional Governor of Western Greece in the 2023 elections as the leader of the coalition "Forward for All," with 59.03% in the first round.